Capturing the Onset of PRC2-Mediated Repressive Domain Formation

Polycomb repressive complex 2 (PRC2) maintains gene silencing by catalyzing methylation of histone H3 at lysine 27 (H3K27me2/3) within chromatin. By designing a system whereby PRC2-mediated repressive domains were collapsed and then reconstructed in an inducible fashion in vivo, a two-step mechanism...

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Udgivet i:Mol Cell
Main Authors: Oksuz, Ozgur, Narendra, Varun, Lee, Chul-Hwan, Descostes, Nicolas, LeRoy, Gary, Raviram, Ramya, Blumenberg, Lili, Karch, Kelly, Rocha, Pedro P., Garcia, Benjamin A., Skok, Jane A., Reinberg, Danny
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7700016/
https://ncbi.nlm.nih.gov/pubmed/29932905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.05.023
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