Disentangling the Complexity of HGF Signaling by Combining Qualitative and Quantitative Modeling

Signaling pathways are characterized by crosstalk, feedback and feedforward mechanisms giving rise to highly complex and cell-context specific signaling networks. Dissecting the underlying relations is crucial to predict the impact of targeted perturbations. However, a major challenge in identifying...

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Vydáno v:PLoS Comput Biol
Hlavní autoři: D’Alessandro, Lorenza A., Samaga, Regina, Maiwald, Tim, Rho, Seong-Hwan, Bonefas, Sandra, Raue, Andreas, Iwamoto, Nao, Kienast, Alexandra, Waldow, Katharina, Meyer, Rene, Schilling, Marcel, Timmer, Jens, Klamt, Steffen, Klingmüller, Ursula
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2015
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4427303/
https://ncbi.nlm.nih.gov/pubmed/25905717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1004192
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