Identification of DNA cleavage- and recombination-specific hnRNP cofactors for activation-induced cytidine deaminase

Activation-induced cytidine deaminase (AID) is essential for antibody class switch recombination (CSR) and somatic hypermutation (SHM). AID originally was postulated to function as an RNA-editing enzyme, based on its strong homology with apolipoprotein B mRNA-editing enzyme, catalytic polypeptide 1...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Autores principales: Hu, Wenjun, Begum, Nasim A., Mondal, Samiran, Stanlie, Andre, Honjo, Tasuku
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2015
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4426456/
https://ncbi.nlm.nih.gov/pubmed/25902538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1506167112
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