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Differential regulation of S-region hypermutation and class-switch recombination by noncanonical functions of uracil DNA glycosylase
Activation-induced cytidine deaminase (AID) is essential to class-switch recombination (CSR) and somatic hypermutation (SHM) in both V region SHM and S region SHM (s-SHM). Uracil DNA glycosylase (UNG), a member of the base excision repair (BER) complex, is required for CSR. Strikingly, however, UNG...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3964042/ https://ncbi.nlm.nih.gov/pubmed/24591630 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1402391111 |
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