The Histone Chaperone Spt6 Is Required for Activation-induced Cytidine Deaminase Target Determination through H3K4me3 Regulation

H3K4me3 plays a critical role in the activation-induced cytidine deaminase (AID)-induced DNA cleavage of switch (S) regions in the immunoglobulin heavy chain (IgH) locus during class-switch recombination (CSR). The histone chaperone complex facilitates chromatin transcription (FACT) is responsible f...

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Detalhes bibliográficos
Main Authors: Begum, Nasim A., Stanlie, Andre, Nakata, Mikiyo, Akiyama, Hideo, Honjo, Tasuku
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3463360/
https://ncbi.nlm.nih.gov/pubmed/22843687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.351569
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