Degree of Recruitment of DOT1L to MLL-AF9 Defines Level of H3K79 Di- and Tri-methylation on Target Genes and Transformation Potential

The MLL gene is a common target of chromosomal translocations found in human leukemia. MLL-fusion leukemia has a consistently poor outcome. One of the most common translocation partners is AF9 (MLLT3). MLL-AF9 recruits DOT1L, a histone 3 lysine 79 methyltransferase (H3K79me1/me2/me3), leading to abe...

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Détails bibliographiques
Publié dans:Cell Rep
Auteurs principaux: Kuntimaddi, Aravinda, Achille, Nicholas J., Thorpe, Jeremy, Lokken, Alyson A., Singh, Ritambhara, Hemenway, Charles S., Adli, Mazhar, Zeleznik-Le, Nancy J., Bushweller, John H.
Format: Artigo
Langue:Inglês
Publié: 2015
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4426023/
https://ncbi.nlm.nih.gov/pubmed/25921540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.04.004
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