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Steric gate residues of Y-family DNA polymerases DinB and pol kappa are crucial for dNTP-induced conformational change
Discrimination against ribonucleotides by DNA polymerases is critical to preserve DNA integrity. For many DNA polymerases, including those of the Y family, rNTP discrimination has been attributed to steric clashes between a residue near the active site, the steric gate, and the 2′-hydroxyl of the in...
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| Gepubliceerd in: | DNA Repair (Amst) |
|---|---|
| Hoofdauteurs: | , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2015
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4425993/ https://ncbi.nlm.nih.gov/pubmed/25684709 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2015.01.012 |
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