Iron-induced Local Complement Component 3 (C3) Up-regulation via Non-canonical Transforming Growth Factor (TGF)-β Signaling in the Retinal Pigment Epithelium

Dysregulation of iron homeostasis may be a pathogenic factor in age-related macular degeneration (AMD). Meanwhile, the formation of complement-containing deposits under the retinal pigment epithelial (RPE) cell layer is a pathognomonic feature of AMD. In this study, we investigated the molecular mec...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Li, Yafeng, Song, Delu, Song, Ying, Zhao, Liangliang, Wolkow, Natalie, Tobias, John W., Song, Wenchao, Dunaief, Joshua L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4424331/
https://ncbi.nlm.nih.gov/pubmed/25802332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.645903
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