Mutation of Androgen Receptor N-Terminal Phosphorylation Site Tyr-267 Leads to Inhibition of Nuclear Translocation and DNA Binding

Reactivation of androgen receptor (AR) may drive recurrent prostate cancer in castrate patients. Ack1 tyrosine kinase is overexpressed in prostate cancer and promotes castrate resistant xenograft tumor growth and enhances androgen target gene expression and AR recruitment to enhancers. Ack1 phosphor...

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Bibliographic Details
Published in:PLoS One
Main Authors: Karaca, Mehmet, Liu, Yuanbo, Zhang, Zhentao, De Silva, Dinuka, Parker, Joel S., Earp, H. Shelton, Whang, Young E.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2015
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4423977/
https://ncbi.nlm.nih.gov/pubmed/25950519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0126270
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