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Interaction between androgen receptor and coregulator SLIRP is regulated by Ack1 tyrosine kinase and androgen

Aberrant activation of the androgen receptor (AR) may play a critical role in castration resistant prostate cancer. After ligand binding, AR is recruited to the androgen responsive element (ARE) sequences on the DNA where AR interaction with coactivators and corepressors modulates transcription. We...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: De Silva, Dinuka, Zhang, Zhentao, Liu, Yuanbo, Parker, Joel S., Xu, Chenxi, Cai, Ling, Wang, Gang Greg, Earp, H. Shelton, Whang, Young E.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6901447/
https://ncbi.nlm.nih.gov/pubmed/31819114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-55057-2
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