Inhibitors of the Candida albicans Major Facilitator Superfamily Transporter Mdr1p Responsible for Fluconazole Resistance

OBJECTIVE: To identify a novel class of inhibitors of fungal transporters involved in drug resistance. METHODS: A series of structurally-related low molecular mass compounds was synthesized using combinatorial chemistry of a cyclobutene-dione (squarile) core. These compounds were screened for their...

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Bibliographic Details
Published in:PLoS One
Main Authors: Keniya, Mikhail V., Fleischer, Edmond, Klinger, Anette, Cannon, Richard D., Monk, Brian C.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2015
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4423874/
https://ncbi.nlm.nih.gov/pubmed/25951180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0126350
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