The Monoamine Oxidase A Inhibitor Clorgyline Is a Broad-Spectrum Inhibitor of Fungal ABC and MFS Transporter Efflux Pump Activities Which Reverses the Azole Resistance of Candida albicans and Candida glabrata Clinical Isolates

Resistance to the commonly used azole antifungal fluconazole (FLC) can develop due to overexpression of ATP-binding cassette (ABC) and major facilitator superfamily (MFS) plasma membrane transporters. An approach to overcoming this resistance is to identify inhibitors of these efflux pumps. We have...

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Detalhes bibliográficos
Main Authors: Holmes, Ann R., Keniya, Mikhail V., Ivnitski-Steele, Irena, Monk, Brian C., Lamping, Erwin, Sklar, Larry A., Cannon, Richard D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Biologic Response Modifiers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3294898/
https://ncbi.nlm.nih.gov/pubmed/22203607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.05706-11
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