The Monoamine Oxidase A Inhibitor Clorgyline Is a Broad-Spectrum Inhibitor of Fungal ABC and MFS Transporter Efflux Pump Activities Which Reverses the Azole Resistance of Candida albicans and Candida glabrata Clinical Isolates

Resistance to the commonly used azole antifungal fluconazole (FLC) can develop due to overexpression of ATP-binding cassette (ABC) and major facilitator superfamily (MFS) plasma membrane transporters. An approach to overcoming this resistance is to identify inhibitors of these efflux pumps. We have...

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Bibliographische Detailangaben
Hauptverfasser: Holmes, Ann R., Keniya, Mikhail V., Ivnitski-Steele, Irena, Monk, Brian C., Lamping, Erwin, Sklar, Larry A., Cannon, Richard D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2012
Schlagworte:
Biologic Response Modifiers
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3294898/
https://ncbi.nlm.nih.gov/pubmed/22203607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.05706-11
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