ABC Transporter Cdr1p Contributes More than Cdr2p Does to Fluconazole Efflux in Fluconazole-Resistant Candida albicans Clinical Isolates

Fluconazole (FLC) remains the antifungal drug of choice for non-life-threatening Candida infections, but drug-resistant strains have been isolated during long-term therapy with azoles. Drug efflux, mediated by plasma membrane transporters, is a major resistance mechanism, and clinically significant...

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Detalhes bibliográficos
Main Authors: Holmes, Ann R., Lin, Ya-Hsun, Niimi, Kyoko, Lamping, Erwin, Keniya, Mikhail, Niimi, Masakazu, Tanabe, Koichi, Monk, Brian C., Cannon, Richard D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
Assuntos:
Mechanisms of Resistance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2573144/
https://ncbi.nlm.nih.gov/pubmed/18710914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00463-08
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