Tris (dibenzylideneacetone) dipalladium (Tris DBA), an N-myristoyltransferase 1 inhibitor, is effective against melanoma growth in vitro and in vivo

PURPOSE: Melanoma is a solid tumor that is notoriously resistant to chemotherapy, and its incidence is rapidly increasing. Recently, several signaling pathways have been demonstrated to contribute to melanoma tumorigenesis, including constitutive activation of MAP kinase, Akt and Stat-3. The activat...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Bhandarkar, Sulochana S., Bromberg, Jacqueline, Carrillo, Carol, Selvakumar, Ponniah, Sharma, Rajendra K, Perry, Betsy N, Govindarajan, Baskaran, Fried, Levi, Sohn, Allie, Reddy, Kalpana, Arbiser, Jack L
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4423743/
https://ncbi.nlm.nih.gov/pubmed/18794083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-08-0405
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