Structure–activity exploration of a small-molecule Lipid II inhibitor

We have recently identified low-molecular weight compounds that act as inhibitors of Lipid II, an essential precursor of bacterial cell wall biosynthesis. Lipid II comprises specialized lipid (bactoprenol) linked to a hydrophilic head group consisting of a peptidoglycan subunit (N-acetyl glucosamine...

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Dettagli Bibliografici
Pubblicato in:Drug Des Devel Ther
Autori principali: Fletcher, Steven, Yu, Wenbo, Huang, Jing, Kwasny, Steven M, Chauhan, Jay, Opperman, Timothy J, MacKerell, Alexander D, de Leeuw, Erik PH
Natura: Artigo
Lingua:Inglês
Pubblicazione: Dove Medical Press 2015
Soggetti:
Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4422293/
https://ncbi.nlm.nih.gov/pubmed/25987836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S79504
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