A mechanistic model of tau amyloid aggregation based on direct observation of oligomers

Protein aggregation plays a key role in neurodegenerative disease, giving rise to small oligomers that may become cytotoxic to cells. The fundamental microscopic reactions taking place during aggregation, and their rate constants, have been difficult to determine due to lack of suitable methods to i...

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Udgivet i:Nat Commun
Main Authors: Shammas, Sarah L., Garcia, Gonzalo A., Kumar, Satish, Kjaergaard, Magnus, Horrocks, Mathew H., Shivji, Nadia, Mandelkow, Eva, Knowles, Tuomas P.J., Mandelkow, Eckhard, Klenerman, David
Format: Artigo
Sprog:Inglês
Udgivet: Nature Pub. Group 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4421837/
https://ncbi.nlm.nih.gov/pubmed/25926130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8025
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