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Bayesian sequential monitoring design for two-arm randomized clinical trials with noncompliance
In early-phase clinical trials, interim monitoring is commonly conducted based on the estimated intent-to-treat effect, which is subject to bias in the presence of noncompliance. To address this issue, we propose a Bayesian sequential monitoring trial design based on the estimation of the causal eff...
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| Опубликовано в: : | Stat Med |
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| Главные авторы: | , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2015
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4420650/ https://ncbi.nlm.nih.gov/pubmed/25756852 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sim.6474 |
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