Protective effect of heme oxygenase induction in ethinylestradiol-induced cholestasis

Estrogen-induced cholestasis is characterized by impaired hepatic uptake and biliary bile acids secretion because of changes in hepatocyte transporter expression. The induction of heme oxygenase-1 (HMOX1), the inducible isozyme in heme catabolism, is mediated via the Bach1/Nrf2 pathway, and protects...

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Pubblicato in:J Cell Mol Med
Autori principali: Muchova, Lucie, Vanova, Katerina, Suk, Jakub, Micuda, Stanislav, Dolezelova, Eva, Fuksa, Leos, Cerny, Dalibor, Farghali, Hassan, Zelenkova, Miroslava, Lenicek, Martin, Wong, Ronald J, Vreman, Hendrik J, Vitek, Libor
Natura: Artigo
Lingua:Inglês
Pubblicazione: BlackWell Publishing Ltd 2015
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Original Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4420596/
https://ncbi.nlm.nih.gov/pubmed/25683492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.12401
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