A Phase 1 Randomized, Open Label, Rectal Safety, Acceptability, Pharmacokinetic, and Pharmacodynamic Study of Three Formulations of Tenofovir 1% Gel (the CHARM-01 Study)

OBJECTIVES: The CHARM-01 study characterized the safety, acceptability, pharmacokinetics (PK), and pharmacodynamics (PD) of three tenofovir (TFV) gels for rectal application. The vaginal formulation (VF) gel was previously used in the CAPRISA 004 and VOICE vaginal microbicide Phase 2B trials and the...

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Publicat a:PLoS One
Autors principals: Mcgowan, Ian, Cranston, Ross D., Duffill, Kathryn, Siegel, Aaron, Engstrom, Jarret C., Nikiforov, Alexyi, Jacobson, Cindy, Rehman, Khaja K., Elliott, Julie, Khanukhova, Elena, Abebe, Kaleab, Mauck, Christine, Spiegel, Hans M. L., Dezzutti, Charlene S., Rohan, Lisa C., Marzinke, Mark A., Hiruy, Hiwot, Hendrix, Craig W., Richardson-Harman, Nicola, Anton, Peter A.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2015
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4420274/
https://ncbi.nlm.nih.gov/pubmed/25942472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0125363
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