A Phase 1 Randomized, Blinded Comparison of the Pharmacokinetics and Colonic Distribution of Three Candidate Rectal Microbicide Formulations of Tenofovir 1% Gel with Simulated Unprotected Sex (CHARM-02)

CHARM-02 is a crossover, double-blind, randomized trial to compare the safety and pharmacokinetics of three rectally applied tenofovir 1% gel candidate rectal microbicides of varying osmolalities: vaginal formulation (VF) (3111 mOsmol/kg), the reduced glycerin vaginal formulation (RGVF) (836 mOsmol/...

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Detalhes bibliográficos
Publicado no:AIDS Res Hum Retroviruses
Main Authors: Hiruy, Hiwot, Fuchs, Edward J., Marzinke, Mark A., Bakshi, Rahul P., Breakey, Jennifer C., Aung, Wutyi S., Manohar, Madhuri, Yue, Chen, Caffo, Brian S., Du, Yong, Abebe, Kaleab Z., Spiegel, Hans M.L., Rohan, Lisa C., McGowan, Ian, Hendrix, Craig W.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2015
Assuntos:
Clinical Trials/Clinical Studies
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4651050/
https://ncbi.nlm.nih.gov/pubmed/26227279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/aid.2015.0098
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