A Phase 1 Randomized, Blinded Comparison of the Pharmacokinetics and Colonic Distribution of Three Candidate Rectal Microbicide Formulations of Tenofovir 1% Gel with Simulated Unprotected Sex (CHARM-02)

CHARM-02 is a crossover, double-blind, randomized trial to compare the safety and pharmacokinetics of three rectally applied tenofovir 1% gel candidate rectal microbicides of varying osmolalities: vaginal formulation (VF) (3111 mOsmol/kg), the reduced glycerin vaginal formulation (RGVF) (836 mOsmol/...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:AIDS Res Hum Retroviruses
Auteurs principaux: Hiruy, Hiwot, Fuchs, Edward J., Marzinke, Mark A., Bakshi, Rahul P., Breakey, Jennifer C., Aung, Wutyi S., Manohar, Madhuri, Yue, Chen, Caffo, Brian S., Du, Yong, Abebe, Kaleab Z., Spiegel, Hans M.L., Rohan, Lisa C., McGowan, Ian, Hendrix, Craig W.
Format: Artigo
Langue:Inglês
Publié: Mary Ann Liebert, Inc. 2015
Sujets:
Clinical Trials/Clinical Studies
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4651050/
https://ncbi.nlm.nih.gov/pubmed/26227279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/aid.2015.0098
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