Biological interpretation of genome-wide association studies using predicted gene functions

The main challenge for gaining biological insights from genetic associations is identifying which genes and pathways explain the associations. Here we present DEPICT, an integrative tool that employs predicted gene functions to systematically prioritize the most likely causal genes at associated loc...

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Udgivet i:Nat Commun
Main Authors: Pers, Tune H., Karjalainen, Juha M., Chan, Yingleong, Westra, Harm-Jan, Wood, Andrew R., Yang, Jian, Lui, Julian C., Vedantam, Sailaja, Gustafsson, Stefan, Esko, Tonu, Frayling, Tim, Speliotes, Elizabeth K., Boehnke, Michael, Raychaudhuri, Soumya, Fehrmann, Rudolf S.N., Hirschhorn, Joel N., Franke, Lude
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4420238/
https://ncbi.nlm.nih.gov/pubmed/25597830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms6890
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