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Mechanism of DNA Depurination by Carcinogens in Relation to Cancer Initiation
Depurinating DNA adducts formed by aromatic hydrocarbons and catechol estrogen quinones play a major role in cancer initiation. Most of these adducts depurinate instantaneously, but some guanine adducts depurinate from DNA with half-lives of hours. We report here, that after 10 h at 37 °C, reaction...
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| Veröffentlicht in: | IUBMB Life |
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| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2011
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4418633/ https://ncbi.nlm.nih.gov/pubmed/22162200 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/iub.586 |
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