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How Proteins Bind Macrocycles
The potential utility of synthetic macrocycles as drugs, particularly against low druggability targets such as protein-protein interactions, has been widely discussed. There is little information, however, to guide the design of macrocycles for good target protein-binding activity or bioavailability...
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| Publicado no: | Nat Chem Biol |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4417626/ https://ncbi.nlm.nih.gov/pubmed/25038790 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1584 |
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