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Cryptic binding sites on proteins: definition, detection, and druggability
Many proteins in their unbound structures lack surface pockets appropriately sized for drug binding. Hence, a variety of experimental and computational tools have been developed for the identification of cryptic sites that are not evident in the unbound protein but form upon ligand binding, and can...
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| Опубликовано в: : | Curr Opin Chem Biol |
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| Главные авторы: | , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Elsevier Ltd.
2018
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6088748/ https://ncbi.nlm.nih.gov/pubmed/29800865 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cbpa.2018.05.003 |
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