Active displacement of RecA filaments by UvrD translocase activity

The UvrD helicase has been implicated in the disassembly of RecA nucleoprotein filaments in vivo and in vitro. We demonstrate that UvrD utilizes an active mechanism to remove RecA from the DNA. Efficient RecA removal depends on the availability of DNA binding sites for UvrD and/or the accessibility...

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發表在:Nucleic Acids Res
Main Authors: Petrova, Vessela, Chen, Stefanie H., Molzberger, Eileen T., Tomko, Eric, Chitteni-Pattu, Sindhu, Jia, Haifeng, Ordabayev, Yerdos, Lohman, Timothy M., Cox, Michael M.
格式: Artigo
語言:Inglês
出版: Oxford University Press 2015
主題:
Nucleic Acid Enzymes
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4417151/
https://ncbi.nlm.nih.gov/pubmed/25824953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv186
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