Intact Glycosaminoglycans from intervertebral disc-derived notochordal cell conditioned media inhibits neurite growth while maintaining neuronal cell viability

BACKGROUND CONTEXT: Painful human intervertebral discs (IVDs) exhibit nerve growth deep into the IVD. Current treatments for discogenic back pain do not address the underlying mechanisms propagating pain and are often highly invasive or only offer temporary symptom relief. The notochord produces fac...

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Publicado en:Spine J
Main Authors: Purmessur, Devina, Cornejo, Marisa C, Cho, Samuel K, Roughley, Peter J, Linhardt, Robert J, Hecht, Andrew C, Iatridis, James C
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4416992/
https://ncbi.nlm.nih.gov/pubmed/25661435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.spinee.2015.02.003
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