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Intact Glycosaminoglycans from intervertebral disc-derived notochordal cell conditioned media inhibits neurite growth while maintaining neuronal cell viability

BACKGROUND CONTEXT: Painful human intervertebral discs (IVDs) exhibit nerve growth deep into the IVD. Current treatments for discogenic back pain do not address the underlying mechanisms propagating pain and are often highly invasive or only offer temporary symptom relief. The notochord produces fac...

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Vydáno v:Spine J
Hlavní autoři: Purmessur, Devina, Cornejo, Marisa C, Cho, Samuel K, Roughley, Peter J, Linhardt, Robert J, Hecht, Andrew C, Iatridis, James C
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4416992/
https://ncbi.nlm.nih.gov/pubmed/25661435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.spinee.2015.02.003
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