DBA/2J Genetic Background Exacerbates Spontaneous Lethal Seizures but Lessens Amyloid Deposition in a Mouse Model of Alzheimer’s Disease

Alzheimer’s disease (AD) is a leading cause of dementia in the elderly and is characterized by amyloid plaques, neurofibrillary tangles (NFTs) and neuronal dysfunction. Early onset AD (EOAD) is commonly caused by mutations in amyloid precursor protein (APP) or genes involved in the processing of APP...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Jackson, Harriet M., Onos, Kristen D., Pepper, Keating W., Graham, Leah C., Akeson, Ellen C., Byers, Candice, Reinholdt, Laura G., Frankel, Wayne N., Howell, Gareth R.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4416920/
https://ncbi.nlm.nih.gov/pubmed/25933409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0125897
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