Novel hybrid nocodazole analogues as tubulin polymerization inhibitors and their antiproliferative activity

We describe the design, synthesis and SAR profiling of a series of novel combretastatin–nocodazole conjugates as potential anticancer agents. The thiophene ring in the nocodazole moiety was replaced by a substituted phenyl ring from the combretastatin moiety to design novel hybrid analogues. The hyd...

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Veröffentlicht in:Bioorg Med Chem Lett
Hauptverfasser: Kale, Sangram S., Jedhe, Ganesh S., Meshram, Sachin N., Santra, Manas K., Hamel, Ernest, Sanjayan, Gangadhar J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4416488/
https://ncbi.nlm.nih.gov/pubmed/25817588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2015.03.019
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