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Novel hybrid nocodazole analogues as tubulin polymerization inhibitors and their antiproliferative activity
We describe the design, synthesis and SAR profiling of a series of novel combretastatin–nocodazole conjugates as potential anticancer agents. The thiophene ring in the nocodazole moiety was replaced by a substituted phenyl ring from the combretastatin moiety to design novel hybrid analogues. The hyd...
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| 出版年: | Bioorg Med Chem Lett |
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| 主要な著者: | , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2015
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4416488/ https://ncbi.nlm.nih.gov/pubmed/25817588 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2015.03.019 |
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