Effect of Sodium-Glucose Cotransport Inhibition on Polycystic Kidney Disease Progression in PCK Rats

The sodium-glucose-cotransporter-2 (SGLT2) inhibitor dapagliflozin (DAPA) induces glucosuria and osmotic diuresis via inhibition of renal glucose reabsorption. Since increased diuresis retards the progression of polycystic kidney disease (PKD), we investigated the effect of DAPA in the PCK rat model...

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Udgivet i:PLoS One
Main Authors: Kapoor, Sarika, Rodriguez, Daniel, Riwanto, Meliana, Edenhofer, Ilka, Segerer, Stephan, Mitchell, Katharyn, Wüthrich, Rudolf P.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4416041/
https://ncbi.nlm.nih.gov/pubmed/25927597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0125603
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