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Effect of Sodium-Glucose Cotransport Inhibition on Polycystic Kidney Disease Progression in PCK Rats

The sodium-glucose-cotransporter-2 (SGLT2) inhibitor dapagliflozin (DAPA) induces glucosuria and osmotic diuresis via inhibition of renal glucose reabsorption. Since increased diuresis retards the progression of polycystic kidney disease (PKD), we investigated the effect of DAPA in the PCK rat model...

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Bibliografiska uppgifter
I publikationen:PLoS One
Huvudupphovsmän: Kapoor, Sarika, Rodriguez, Daniel, Riwanto, Meliana, Edenhofer, Ilka, Segerer, Stephan, Mitchell, Katharyn, Wüthrich, Rudolf P.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2015
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4416041/
https://ncbi.nlm.nih.gov/pubmed/25927597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0125603
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