Inhibition of Sodium-GlucoseCotransporter 2 with Dapagliflozin in Han: SPRD Rats with Polycystic Kidney Disease

Background/Aims: Dapagliflozin (DAPA) is a selective inhibitor of the sodium-glucose cotransporter 2 (SGLT2) which induces glucosuria and osmotic diuresis. The therapeutic effect of DAPA in progressing stages of polycystic kidney disease (PKD) has not been studied. Methods: We examined the effect of...

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Detalhes bibliográficos
Main Authors: Daniel Rodriguez, Sarika Kapoor, Ilka Edenhofer, Stephan Segerer, Meliana Riwanto, Anja Kipar, Ming Yang, Changlin Mei, Rudolf P. Wüthrich
Formato: Artigo
Idioma:Inglês
Publicado em: Karger Publishers 2015-12-01
Colecção:Kidney & Blood Pressure Research
Assuntos:
Dapagliflozin
Glucosuria
Polycystic kidney disease (PKD)
Sodium glucose cotransporter (SGLT)
Cyst
Acesso em linha:http://www.karger.com/Article/FullText/368540
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