Neuroprotective effects of aldehyde dehydrogenase 2 activation in rotenone-induced cellular and animal models of parkinsonism

Many studies have shown that mitochondrial aldehyde dehydrogenase 2 (ALDH2) functions as a cellular protector against oxidative stress by detoxification of cytotoxic aldehydes. Within dopaminergic neurons, dopamine is metabolized by monoamine oxidase to yield 3,4-dihydroxyphenylacetaldehyde (DOPAL)...

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Detalhes bibliográficos
Publicado no:Exp Neurol
Main Authors: Chiu, Ching-Chi, Yeh, Tu-Hsueh, Lai, Szu-Chia, Wu-Chou, Yah-Huei, Chen, Che-Hong, Mochly-Rosen, Daria, Huang, Yin-Cheng, Chen, Yu-Jie, Chen, Chao-Lang, Chang, Ya-Ming, Wang, Hung-Li, Lu, Chin-Song
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4415848/
https://ncbi.nlm.nih.gov/pubmed/25263579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.expneurol.2014.09.016
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