Corticosteroid insensitive alveolar macrophages from asthma patients; synergistic interaction with a p38 mitogen-activated protein kinase (MAPK) inhibitor

AIMS: Some asthma patients remain symptomatic despite using high doses of inhaled corticosteroids (ICS). We used alveolar macrophages to identify individual patients with insensitivity to corticosteroids and to evaluate the anti-inflammatory effects of a p38 mitogen-activated protein kinase (MAPK) i...

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Detalhes bibliográficos
Publicado no:Br J Clin Pharmacol
Main Authors: Lea, Simon, Harbron, Chris, Khan, Naimat, Booth, George, Armstrong, Jane, Singh, Dave
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2015
Assuntos:
Translational Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4415712/
https://ncbi.nlm.nih.gov/pubmed/25358442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12536
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