Reversal of corticosteroid insensitivity by p38 MAPK inhibition in peripheral blood mononuclear cells from COPD

BACKGROUND: Corticosteroids (CS) have limited efficacy in the treatment of chronic obstructive pulmonary disease (COPD). p38 mitogen-activated protein kinase (MAPK) activation is increased in lung macrophages of COPD. We investigated whether p38 MAPK inhibition can modulate CS insensitivity of perip...

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Foilsithe in:Int J Chron Obstruct Pulmon Dis
Main Authors: Khorasani, Nadia, Baker, Josephine, Johnson, Malcolm, Chung, Kian Fan, Bhavsar, Pankaj K
Formáid: Artigo
Teanga:Inglês
Foilsithe: Dove Medical Press 2015
Ábhair:
Original Research
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4322842/
https://ncbi.nlm.nih.gov/pubmed/25678784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/COPD.S72403
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