The transcription factors Ik-1 and MZF1 downregulate IGF-IR expression in NPM-ALK(+) T-cell lymphoma

BACKGROUND: The type I insulin-like growth factor receptor (IGF-IR) tyrosine kinase promotes the survival of an aggressive subtype of T-cell lymphoma by interacting with nucleophosmin-anaplastic lymphoma kinase (NPM-ALK) oncogenic protein. NPM-ALK(+) T-cell lymphoma exhibits much higher levels of IG...

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Detalhes bibliográficos
Publicado no:Mol Cancer
Main Authors: Vishwamitra, Deeksha, Curry, Choladda V, Alkan, Serhan, Song, Yao-Hua, Gallick, Gary E, Kaseb, Ahmed O, Shi, Ping, Amin, Hesham M
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4415347/
https://ncbi.nlm.nih.gov/pubmed/25884514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12943-015-0324-2
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