Dual inhibition of IGF-IR and ALK as an effective strategy to eradicate NPM-ALK(+) T-cell lymphoma

BACKGROUND: Nucleophosmin-anaplastic lymphoma kinase-expressing (NPM-ALK(+)) T cell lymphoma is an aggressive neoplasm. NPM-ALK, an oncogenic tyrosine kinase, plays a critical role in this lymphoma. Recently, selective ALK inhibitors have emerged as a first-line therapy for this neoplasm. Unfortunat...

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Bibliografiske detaljer
Udgivet i:J Hematol Oncol
Main Authors: George, Bhawana, George, Suraj Konnath, Shi, Wenyu, Haque, Abedul, Shi, Ping, Eskandari, Ghazaleh, Axelson, Magnus, Larsson, Olle, Kaseb, Ahmed O., Amin, Hesham M.
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2019
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6657048/
https://ncbi.nlm.nih.gov/pubmed/31340850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13045-019-0768-8
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