The transcription factors Ik-1 and MZF1 downregulate IGF-IR expression in NPM-ALK(+) T-cell lymphoma

BACKGROUND: The type I insulin-like growth factor receptor (IGF-IR) tyrosine kinase promotes the survival of an aggressive subtype of T-cell lymphoma by interacting with nucleophosmin-anaplastic lymphoma kinase (NPM-ALK) oncogenic protein. NPM-ALK(+) T-cell lymphoma exhibits much higher levels of IG...

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Vydáno v:Mol Cancer
Hlavní autoři: Vishwamitra, Deeksha, Curry, Choladda V, Alkan, Serhan, Song, Yao-Hua, Gallick, Gary E, Kaseb, Ahmed O, Shi, Ping, Amin, Hesham M
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2015
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4415347/
https://ncbi.nlm.nih.gov/pubmed/25884514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12943-015-0324-2
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