Differential phosphorylation of DNA-PKcs regulates the interplay between end-processing and end-ligation during non-homologous end-joining

Non-homologous end-joining (NHEJ) is a major DNA double strand break repair pathway that is conserved in eukaryotes. In vertebrates, NHEJ further acquires end-processing capacities (e.g., hairpin opening) in addition to direct end-ligation. The catalytic subunit of DNA-PK (DNA-PKcs) is a vertebrate...

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Pubblicato in:Mol Cell
Autori principali: Jiang, Wenxia, Crowe, Jennifer L., Liu, Xiangyu, Nakajima, Satoshi, Wang, Yunyue, Li, Chen, Lee, Brian J., Dubois, Richard L., Liu, Chao, Yu, Xiaochun, Lan, Li, Zha, Shan
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4415111/
https://ncbi.nlm.nih.gov/pubmed/25818648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2015.02.024
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