Peripheral indoleamine 2,3-dioxygenase1 is required for comorbid depression-like behavior but does not contribute to neuropathic pain in mice

Chronic pain frequently co-occurs with major depressive disorder but the mechanisms are poorly understood. We investigated the contribution of indoleamine-2,3-dioxygenase-1 (IDO1), a rate-limiting enzyme in the conversion of tryptophan to neurotoxic metabolites to this comorbidity using the spared n...

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Vydáno v:Brain Behav Immun
Hlavní autoři: Zhou, Wenjun, Dantzer, Robert, Budac, David P., Walker, Adam K., Mao-Ying, Qi-Liang, Lee, Anna W., Heijnen, Cobi J., Kavelaars, Annemieke
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4414738/
https://ncbi.nlm.nih.gov/pubmed/25637485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbi.2015.01.013
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