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Peripheral indoleamine 2,3-dioxygenase1 is required for comorbid depression-like behavior but does not contribute to neuropathic pain in mice
Chronic pain frequently co-occurs with major depressive disorder but the mechanisms are poorly understood. We investigated the contribution of indoleamine-2,3-dioxygenase-1 (IDO1), a rate-limiting enzyme in the conversion of tryptophan to neurotoxic metabolites to this comorbidity using the spared n...
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| Publicado en: | Brain Behav Immun |
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| Autores principales: | , , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2015
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4414738/ https://ncbi.nlm.nih.gov/pubmed/25637485 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbi.2015.01.013 |
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