15-oxoeicosatetraenoic acid is a 15-hydroxyprostaglandin dehydrogenase-derived electrophilic mediator of inflammatory signaling pathways

Bioactive lipids govern cellular homeostasis and pathogenic inflammatory processes. Current dogma holds that bioactive lipids, such as prostaglandins and lipoxins, are inactivated by 15-hydroxyprostaglandin dehydrogenase (15PGDH). In contrast, the present results reveal that catabolic “inactivation”...

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Gepubliceerd in:Chem Biol Interact
Hoofdauteurs: Snyder, Nathaniel W., Golin-Bisello, Franca, Gao, Yang, Blair, Ian A., Freeman, Bruce A., Wendell, Stacy Gelhaus
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2014
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4414684/
https://ncbi.nlm.nih.gov/pubmed/25450232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cbi.2014.10.029
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