EPI-001 is a selective peroxisome proliferator-activated receptor-gamma modulator with inhibitory effects on androgen receptor expression and activity in prostate cancer

The androgen receptor (AR) is a driver of prostate cancer (PCa) cell growth and disease progression. Therapies for advanced PCa exploit AR dependence by blocking the production or action of androgens, but these interventions inevitably fail via multiple mechanisms including mutation or deletion of t...

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Vydáno v:Oncotarget
Hlavní autoři: Brand, Lucas J., Olson, Margaret E., Ravindranathan, Preethi, Guo, Hong, Kempema, Aaron M., Andrews, Timothy E., Chen, Xiaoli, Raj, Ganesh V., Harki, Daniel A., Dehm, Scott M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2015
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4414155/
https://ncbi.nlm.nih.gov/pubmed/25669987
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