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TLR7 induces anergy in human CD4(+) T cells

Pattern recognition of microbes by Toll-like receptors (TLR) is critical for innate immune system activation. Although TLRs are expressed in human CD4(+) T cells, their function is not well understood. Here we demonstrate that engaging TLR7 in CD4(+) T cells induces intracellular calcium flux with a...

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Detalhes bibliográficos
Publicado no:Nat Immunol
Main Authors: Dominguez-Villar, Margarita, Gautron, Anne-Sophie, de Marcken, Marine, Keller, Marla J., Hafler, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4413902/
https://ncbi.nlm.nih.gov/pubmed/25401424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3036
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