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AKT isoforms modulate Th1‐like Treg generation and function in human autoimmune disease

Foxp3(+) regulatory T cells (Tregs) exhibit plasticity, which dictates their function. Secretion of the inflammatory cytokine IFNγ, together with the acquisition of a T helper 1 (Th1)‐like effector phenotype as observed in cancer, infection, and autoimmune diseases, is associated with loss of Treg s...

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Publicado en:EMBO Rep
Autores principales: Kitz, Alexandra, de Marcken, Marine, Gautron, Anne‐Sophie, Mitrovic, Mitja, Hafler, David A, Dominguez‐Villar, Margarita
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2016
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4967959/
https://ncbi.nlm.nih.gov/pubmed/27312110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201541905
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