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Expression of a site-specific endonuclease stimulates homologous recombination in mammalian cells.

Double-strand breaks introduced into DNA in vivo have been shown to enhance homologous recombination in a variety of chromosomal and extrachromosomal loci in Saccharomyces cerevisiae. To introduce double-strand breaks in DNA at defined locations in mammalian cells, we have constructed a mammalian ex...

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Main Authors: Rouet, P, Smih, F, Jasin, M
格式: Artigo
語言:Inglês
出版: 1994
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC44138/
https://ncbi.nlm.nih.gov/pubmed/8016116
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