Expression of a site-specific endonuclease stimulates homologous recombination in mammalian cells.
Double-strand breaks introduced into DNA in vivo have been shown to enhance homologous recombination in a variety of chromosomal and extrachromosomal loci in Saccharomyces cerevisiae. To introduce double-strand breaks in DNA at defined locations in mammalian cells, we have constructed a mammalian ex...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1994
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC44138/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8016116/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.13.6064 |
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