Variants in Complement Factor H and Complement Factor H-Related Protein Genes, CFHR3 and CFHR1, Affect Complement Activation in IgA Nephropathy

Complement activation is common in patients with IgA nephropathy (IgAN) and associated with disease severity. Our recent genome-wide association study of IgAN identified susceptibility loci on 1q32 containing the complement regulatory protein-encoding genes CFH and CFHR1–5, with rs6677604 in CFH as...

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Udgivet i:J Am Soc Nephrol
Main Authors: Zhu, Li, Zhai, Ya-Ling, Wang, Feng-Mei, Hou, Ping, Lv, Ji-Cheng, Xu, Da-Min, Shi, Su-Fang, Liu, Li-Jun, Yu, Feng, Zhao, Ming-Hui, Novak, Jan, Gharavi, Ali G., Zhang, Hong
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Nephrology 2015
Fag:
Clinical Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4413755/
https://ncbi.nlm.nih.gov/pubmed/25205734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2014010096
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