Deletion Variants of CFHR1 and CFHR3 Associate with Mesangial Immune Deposits but Not with Progression of IgA Nephropathy

Activation of complement through the alternative pathway has a key role in the pathogenesis of IgA nephropathy (IgAN). Large, international, genome-wide association studies have shown that deletion of complement factor H–related genes 1 and 3 (CFHR3,1Δ) is associated with a reduced risk of developin...

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Detalhes bibliográficos
Publicado no:J Am Soc Nephrol
Main Authors: Jullien, Perrine, Laurent, Blandine, Claisse, Guillaume, Masson, Ingrid, Dinic, Miriana, Thibaudin, Damien, Berthoux, Francois, Alamartine, Eric, Mariat, Christophe, Maillard, Nicolas
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Nephrology 2018
Assuntos:
Clinical Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5791061/
https://ncbi.nlm.nih.gov/pubmed/29114042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2017010019
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